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SAR-260301 treatment leads to a statistically significant tumor growth inhibition as measured by a ΔT/ΔC of 39% (p = 0
Smiles: O[C@H]1[C@@H](CCC[C@@H]1N1C2=CC=CC=C2OC2C=CC=CC1=2)NS(=O)(=O)C1C=CC(=CC=1)OC(F)(F)F
CAS Number: 2446154-84-1
4-dimethylphenyl)-N-[(1E)-[(2
ATX inhibitor 5 20529 SAR-260301 treatment leads to aATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15. 3 nM. ATX inhibitor 5 shows anti hepatofibrosis effects and reduces CCl4 induced hepatic fibrosis level prominently. Product information CAS Number: 2402772 45 4 Molecular Weight: 474. 87 Formula: C22H18ClF3N6O Chemical Name: N' [(1E) (4 chlorophenyl)methylidene] 4 {[3 (trifluoromethyl)phenyl]amino} 5H,6H,7H,8H pyrido[4,3 d]pyrimidine 6 carbohydrazide Smiles: